Current Issue : October-December Volume : 2016 Issue Number : 4 Articles : 3 Articles
The present study aimed to formulate orodispersible tablets of deferasirox to increase its solubility and to enhance the patient compliance, provide a quick onset of action, as compared to marketed formulations. Dispersible tablets are easier to administer or swallow than capsule for pediatrics, dysphasic patients, mentally ill, uncooperative and nauseated patients, those with conditions of motion sickness sudden episodes of allergic attacks or coughing. Deferasirox is indicated for treatment of chronic iron overloaded caused by blood transfusion patients with Myelodysplastic syndrome, sickle cell diseases, beta-thalassemia and other anemia. Orodispersible tablets were prepared by direct compression technique using 3 different superdisintegrants like as crospovidone, croscarmellose sodium and sodium starch glycolate. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; IR spectroscopy, tablet hardness, friability, wetting time, disintegration time and in-vitro drug release. IR studies indicated that there was no interaction between the drug and excipients. Tablet hardness and friability indicated good mechanical strength of tablets. Wetting time decreased from 59 to 53 sec by increasing the superdisintegrants concentration from 4% to 12% w/w of tablets. The F9 formulation which was prepared by using the 12% of crospovidone showed the increase the drug release rate from 47.69±0.02 to 99.45±0.05% after 20 min. The F9 formulation with disintegration time 124 sec and dissolution rate 99.45±0.05 was selected as best formulation. Formulation F9 compared with conventional marketed formulation and F9 formulation was found to be superior....
To formulate Helicters isora Linn fruit extract in to a gel and evaluate the antimicrobial activity. The aqueous extract of dried fruit of Helicters isora Linn was subjected to antimicrobial activity. The aqueous extract of dried fruits of Helicters isora Linn were subjected to preliminary phytochemical evaluations and antibacterial activity using cup plate method in concentration of 1% and 2%. The bacterial cultures selected for testing’s included S. typhi and S. aureus. The aqueous extract showed inhibition in growth of bacterial culture and slightly better activity against S. aureus as compaired to S. typhi. The different gel formulations of aqueous extract of Helicteres isora Linn were prepared by using polymers carbopol 934 and HPMC by varying their concentration. These formulations were evaluated for physical parameters, drug content, pH, viscosity, extrudability, spreadability, in-vitro drug release and stability study. The formulation with carbopol 934 was found to be more promising as it shows better physicochemical characteristics and drug release compared to other formulations....
The purpose of this research was to study whether the bioavailability of ramipril could be improved by administering lovastatin solid lipid nanoparticles (SLN) duodenally to rats. Ramipril SLN were developed using triglycerides by solvent emulsification followed by ultrasonication. Particle size and zeta potential were measured by photon correlation spectroscopy. The solid state of the drug in the SLN and lipid modification was characterized. Bioavailability studies were conducted in male Wistar rats after intraduodenal administration of ramipril suspension and SLN. Stable ramipril SLN having a mean avg size 47.77 nm and a zeta potential range of –16 to –21 mV were developed. About 42% was entrapped in the SLN. Ramipril was dispersed in an amorphous state and triglycerides were in β1 form in the SLN. In vitro stability studies showed the slow release and stability of ramipril SLN. The relative bioavailability of ramipril SLN was increased by 2.5 times compared with the reference ramipril suspension....
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